SEARCHCOHORTobstetrics and gynecology, critical care

cohort·obstetrics and gynecology, critical care, hematology, internal medicine·PMC10144849

Prolongation of Pregnancy in Patients with HELLP Syndrome Using Methylprednisolone: A Retrospective Multicentric Analysis

Life · 4 authors, 3 centres

AI SUMMARY

FIDELITY 100%

POPULATION138 pregnant women with HELLP syndrome at two university hospitals in Germany.

INTERVENTIONIntravenous methylprednisolone (64 mg for 10 days, with a 50% dosage reduction every other day) for prolongation of pregnancy.

COMPARISONRapid delivery following diagnosis (two control groups).

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

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TL;DR

This retrospective multicentric analysis compared the effects of methylprednisolone treatment versus rapid delivery in pregnant women with HELLP syndrome. The study found that methylprednisolone significantly prolonged pregnancy and improved maternal platelet counts and neonatal outcomes.

Full summary

909 CHARS

A retrospective analysis was conducted on 138 pregnant women with HELLP syndrome diagnosed between 1990 and 2013 at two German university hospitals. The treatment group (n=65) received intravenous methylprednisolone, while two control groups (n=45 and n=28) were managed with rapid delivery. The central results indicated that methylprednisolone treatment was associated with a median pregnancy prolongation of 4 days and a significantly greater increase in maternal platelet counts compared to one control group. Severe neonatal complications, including sepsis and infant death, were significantly lower in the treatment group. Limitations include the study's retrospective design and differences between control groups. The findings suggest that in a selected clinical setting, methylprednisolone may improve maternal and neonatal outcomes by prolonging pregnancy and stabilizing maternal laboratory values.

PICO

PPOPULATION

138 pregnant women with HELLP syndrome at two university hospitals in Germany.

IINTERVENTION

Intravenous methylprednisolone (64 mg for 10 days, with a 50% dosage reduction every other day) for prolongation of pregnancy.

OOUTCOME

Gestational prolongation, maternal platelet count changes, and neonatal complications (sepsis, ventilation, infant death).

STUDY TYPE

cohort

SPECIALTY

obstetrics and gynecology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10144849

Prolongation of Pregnancy in Patients with HELLP Syndrome Using Methylprednisolone: A Retrospective Multicentric Analysis

Life

READ THE FULL PAPER

ABSTRACT

Background: Immediate delivery is an established concept for preventing life-threatening complications in mothers with HELLP syndrome; however, it is associated with preterm births. Methods: Cases of HELLP syndrome diagnosed at the university hospitals of Halle and Magdeburg (Germany) were analyzed retrospectively. Each patient of the treatment group was administered 64 mg of methylprednisolone (MP) intravenously for 10 days, with the dosage being reduced by 50% every other day in patients from Halle (n = 65). Almost immediate delivery was performed in the control groups (n = 45, Halle; n = 28, Magdeburg). Results: Pregnancies in the treatment group were prolonged by 4 days (median 1–55 days). The platelet counts increased from 76,060 ± 22,900/μL to 117,430 ± 39,065/μL in the MP group compared with an increase from 66,500 ± 25,852/μL to 83,430 ± 34,608/μL in control group 1 and from 78,890 ± 19,100/μL to 131,080 ± 50,900/µL in control group 2 ( p < 0.001). Severe neonatal complications were significantly reduced in the treatment group ( p < 0.05): sepsis, 9.25% vs. 24%; ventilation, 44.6% vs. 46.5%; and infant death, 1.6% vs. 8.6%. Conclusions: In a selected collective of patients with HELLP syndrome, prolongation of pregnancy using MP treatment improved maternal and neonatal outcomes.

CITATION EXPORT

Anna Katharina Hosten, Jennifer Bonitz, Volker Thäle et al.. Prolongation of Pregnancy in Patients with HELLP Syndrome Using Methylprednisolone: A Retrospective Multicentric Analysis. Life. (2023). https://doi.org/10.3390/life13041013

AUTHORS

4 · 3 CENTRES

Anna Katharina Hosten, Jennifer Bonitz, Volker Thäle, Michael Tchirikov

1Department of Obstetrics and Prenatal Medicine, Martin-Luther-University of Halle-Wittenberg, 06120 Halle (Saale), Germany
2Department of Paediatrics, Heinrich-Braun-Klinikum Zwickau, 08060 Zwickau, Germany
3Department of Gynecology and Obstetrics, Helios Hospital Sangerhausen, 06526 Sangerhausen, Germany

EDITOR / REVIEWER

Ido Ben-Ami