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TL;DR
MP pretreatment at two doses improved colon morphology, restored antioxidant enzyme activities, reduced lipid peroxidation, and activated the Nrf2-Keap1 signaling pathway.
Food Science & Nutrition · 9 authors, 4 centres
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MP pretreatment at two doses improved colon morphology, restored antioxidant enzyme activities, reduced lipid peroxidation, and activated the Nrf2-Keap1 signaling pathway.
MP pretreatment at 300 and 600 mg/kg was evaluated by assessing body weight, visceral index, colon histomorphology, and molecular markers via ELISA, real-time PCR, and western blot. MP pretreatment effectively protected the intestine from cyclophosphamide-induced injury by improving colon tissue morphology and villus structure, increasing SOD, CAT, and GSH-Px activities, and reducing MDA content in serum and colon tissues. MP significantly increased mRNA expression of SOD, GSH-Px, HO-1, and Nrf2 in colon tissues. Western blot analysis showed that Nrf2 protein was significantly upregulated while Keap1 was significantly downregulated by MP in a dose-dependent manner.