other·preclinical research, biomedical research, nutrition, antioxidants, obstetrics and gynecology·PMC10494625
Protective potential of fresh orange juice against zinc oxide nanoparticles‐induced trans‐placental and trans‐generational toxicity in mice
Food Science & Nutrition · 9 authors, 4 centres
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This preclinical mouse study examined whether oral exposure of pregnant F0 mothers to zinc oxide nanoparticles (ZnO NPs) during the organogenetic period causes trans-placental and trans-generational hepatotoxicity and teratogenicity, and whether co-administration with fresh orange juice (OJ) is protective. ZnO NP exposure caused decreased maternal and offspring body weight, increased liver weight, elevated liver enzymes, histopathological liver damage, and fetal malformations in F1 pups and F1 offspring, while OJ co-administration ameliorated these toxicities.
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Twenty-eight pregnant F0 mice were randomized into four groups (n=7): control, ZnO NPs alone, ZnO NPs plus fresh orange juice (OJ), and OJ alone. Fifty percent of dams underwent cesarean section on gestational day 18 for pup evaluation; the remaining delivered naturally, and F1 offspring were examined at postnatal week 8. ZnO NP-exposed mothers and offspring showed significantly decreased body weight, increased liver weight, and elevated serum ALT, AST, and ALP levels compared to controls (p≤.05). Histopathological analysis revealed disrupted central veins, hepatocyte damage, pyknotic nuclei, and activated Kupffer cells in ZnO NP-exposed mothers and offspring. F1 pups exhibited morphological deviations including limb defects, open eyelids, and short tails. OJ co-administration ameliorated all measured toxicities. FRAP assays indicated reduced hepatic antioxidant capacity in NP-exposed groups.
