Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
MedComm · 11 authors, 1 centre
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FIDELITY 100%
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The authors describe how PTMs dynamically expand the functional repertoire of proteins beyond the twenty standard amino acids, enabling rapid regulation on physiological and developmental timescales.
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The authors describe how PTMs dynamically expand the functional repertoire of proteins beyond the twenty standard amino acids, enabling rapid regulation on physiological and developmental timescales. Specific examples include arginine methylation of NF-κB modulating inflammatory gene expression and aberrant EZH2-mediated methylation promoting tumorigenesis. Therapeutic inhibitors targeting methylation enzymes have entered clinical trials.
