Medicine · 5 authors, 5 centres
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This retrospective nationwide population-based cohort study in Taiwan compared 56,785 PPI users with 56,785 propensity-score-matched controls and found that PPI use was associated with a significantly increased risk of developing Parkinson's disease.
This retrospective, nationwide, population-based cohort study used Taiwan's National Health Insurance Research Database from 1999 to 2011, enrolling 56,785 PPI users and 56,785 propensity score-matched controls by age, sex, cohort entry year, and comorbidity. Over a median follow-up of 5.0 years, 366 PPI users developed PD. The incidence rate of PD was 133.2 versus 90.0 per 100,000 person-years in PPI users versus non-users, yielding an adjusted hazard ratio of 1.76 (95% CI 1.48–2.08). Subgroup analyses showed the elevated risk persisted regardless of age, sex, and comorbidities. Key limitations include the retrospective observational design, potential residual confounding, and inability to establish causation. Randomized prospective trials are needed to confirm these findings.
