Pumping iron: A multi-omics analysis of two extremophilic algae reveals iron economy management

Proceedings of the National Academy of Sciences of the United States of America · 13 authors, 11 centres

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The authors generated chromosome-scale genome assemblies and transcriptomes for D. salina Bardawil and D. tertiolecta, then performed transcriptomic and proteomic analyses under iron-replete and iron-deplete conditions. A previous study found components of all three pathways forming a supercomplex on the plasma membrane.

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preclinical research

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ORIGINAL PAPER

PMC10372677

Pumping iron: A multi-omics analysis of two extremophilic algae reveals iron economy management

Proceedings of the National Academy of Sciences of the United States of America

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ABSTRACT

Significance Algae play a huge role in CO 2 uptake via photosynthesis and represent an important target for climate crisis mitigation efforts. Most photosynthesis proteins require iron as a cofactor so that insufficient iron often limits algal CO 2 sequestration. With this in mind, we examined a genus of algae in the green plant lineage called Dunaliella that is exceptionally well adapted to low-iron environments. We produced complete genomes, transcriptomes, and proteomes for two species of Dunaliella that hail from radically different environments: one from coastal ocean waters and the other from salt flats. We identified dozens of genes and multiple, complementary strategies for iron uptake and management, such as the replacement of ferredoxin by flavodoxin, which reduces the Fe quota by 6%. Keywords: iron homeostasis, phytoplankton, Chlamydomonas reinhardtii , iron starvation–induced protein (ISIP), flavin biosynthesis

CITATION EXPORT

Lital Davidi, Sean D Gallaher, Eyal Ben-David et al.. Pumping iron: A multi-omics analysis of two extremophilic algae reveals iron economy management. Proceedings of the National Academy of Sciences of the United States of America. (2023). https://doi.org/10.1073/pnas.2305495120

AUTHORS

13 · 11 CENTRES

Lital Davidi, Sean D Gallaher, Eyal Ben-David, Samuel O Purvine, Thomas L Fillmore, Carrie D Nicora, Rory J Craig, Stefan Schmollinger, Sanja Roje, Crysten E Blaby-Haas, Robert P Auber, Jennifer H Wisecaver, Sabeeha S Merchant

aDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095
bCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720
cDepartment of Human Genetics, University of California, Los Angeles, CA 90095
dEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354
eBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354
fInstitute of Biological Chemistry, Washington State University, Pullman, WA 99163
gDepartment of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720
hMolecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720
iDepartment of Biochemistry, Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907
jDepartment of Plant and Microbial Biology, University of California, Berkeley, CA 94720
kDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720