other·geriatrics, research methods, clinical nutrition, endocrinology, internal medicine·PMC10919032
Quantifying carboxymethyl lysine and carboxyethyl lysine in human plasma: clinical insights into aging research using liquid chromatography-tandem mass spectrometry
BMC Biotechnology · 10 authors, 3 centres
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This study developed and validated an LC-MS/MS method for simultaneous quantification of CML and CEL in human plasma, achieving linearity across 0.025–1.500 μmol/L with a lower limit of quantification of 0.025 μmol/L.
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This study developed and validated an LC-MS/MS method for simultaneous quantification of CML and CEL in human plasma, achieving linearity across 0.025–1.500 μmol/L with a lower limit of quantification of 0.025 μmol/L. Intra-day and inter-day relative standard deviations were both below 9%, relative errors within ±4%, and average recoveries were 94.24% for CML and 97.89% for CEL. 7.76% in females). The findings suggest these markers may serve as broad indicators of aging-related glucose metabolism changes, though further validation of underlying mechanisms is needed.
