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TL;DR
Twenty-four patients with rectal carcinoma underwent preoperative DCE-MRI followed by total mesorectal excision, with quantitative parameters calculated using a modified Tofts model.
World Journal of Surgical Oncology · 12 authors, 5 centres
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Twenty-four patients with rectal carcinoma underwent preoperative DCE-MRI followed by total mesorectal excision, with quantitative parameters calculated using a modified Tofts model.
Twenty-four patients with rectal carcinoma underwent preoperative DCE-MRI followed by total mesorectal excision, with quantitative parameters calculated using a modified Tofts model. Whole-mount immunohistochemistry and Masson staining were used to quantify tissue components, and Pearson correlation assessed relationships with imaging parameters. K^trans differed significantly across WHO grades G1, G2, and G3 (F=9.890, P=0.001), as did MTT (F=9.890, P=0.038), CDX-2 (F=4.935, P=0.018), and Ki-67 (F=4.131, P=0.031). ECV differed by extramural venous invasion status (t=-2.113, P=0.046). K^trans correlated strongly with CD34 (r=0.708, P=0.000) and moderately with vimentin (r=0.450, P=0.027); Kep correlated strongly with CD34 (r=0.622, P=0.001); Ve correlated moderately with collagen (r=0.548, P=0.006) and vimentin (r=0.417), and negatively with CDX-2 (r=-0.441, P=0.031); ECV correlated positively with collagen (r=0.558, P=0.005) and negatively with CDX-2 (r=-0.472, P=0.020).