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TL;DR
African American women are noted to have higher breast cancer incidence before age 40 and higher mortality, with cardiovascular disease constituting 35% of non-cancer-related mortality in breast cancer patients aged 50 and older.
Biomedicines · 9 authors, 2 centres
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African American women are noted to have higher breast cancer incidence before age 40 and higher mortality, with cardiovascular disease constituting 35% of non-cancer-related mortality in breast cancer patients aged 50 and older.
African American women are noted to have higher breast cancer incidence before age 40 and higher mortality, with cardiovascular disease constituting 35% of non-cancer-related mortality in breast cancer patients aged 50 and older. The review highlights that anthracyclines cause both acute dose-independent and chronic dose-dependent cardiotoxicity through oxidative stress, topoisomerase 2-beta inactivation, and endothelial dysfunction. The authors note that no risk prediction model has been systematically evaluated for performance or methodological rigor, and recommend baseline cardiac evaluation with monitoring every 3 months for the first 12 months post-therapy followed by annual assessment, particularly for high-risk minority populations.