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RCT·oncology, nutrition, clinical nutrition, dietetics, clinical trial·PMC10571774

Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors

Cancers · 11 authors, 3 centres

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TL;DR

A randomized trial tested a 6-month, self-guided lifestyle intervention using printed and online materials for breast cancer survivors with overweight or obesity. The intervention led to statistically greater weight loss at 6 months compared to a waitlist control group.

Full summary

363 CHARS

Weight loss was maintained from 6 to 12 months post-intervention. The study indicates that a low-resource, self-guided program can produce modest but statistically significant weight loss in this population, though the effect was less than in supervised interventions. Limitations include reliance on self-reported data and the unsupervised nature of the program.

STUDY TYPE

RCT

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10571774

Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors

Cancers

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ABSTRACT

Abstract Simple Summary While resource-intensive lifestyle interventions for breast cancer survivors have proved effective at stimulating positive behavior change and promoting healthy weight loss, integrating these programs into clinical practice is challenging. To address these challenges, we adapted our supervised in-person/telephone Lifestyle, Exercise and Nutrition (LEAN) lifestyle program for breast cancer survivors with overweight or obesity to a 6-month, unsupervised, self-guided program, delivered via printed materials and online videos. We tested the efficacy of the LEAN Self-Guided program on weight loss, diet quality, physical activity, and quality of life. At 6 months, the intervention arm had significantly greater weight loss compared with the waitlist group (mean difference = −1.3 kg, 95% confidence interval [CI] = −2.5, −0.13) and maintained this weight loss from 6 months to 12 months (−0.21 kg; p = 0.75). Low-resource-intensive programs have the potential to be delivered in diverse healthcare settings and may support breast cancer survivors in achieving a healthy body weight. Abstract Background: Lifestyle interventions for breast cancer survivors have proved effective at stimulating positive behavior change and promoting healthy weight loss, although integrating these programs into clinical practice is challenging. We evaluated the effect of a 6-month, unsupervised, self-guided, lifestyle intervention using printed materials and online videos vs. waitlist group on body weight for breast cancer survivors. Methods: The Lifestyle, Exercise and Nutrition (LEAN) Self-Guided trial randomized breast cancer survivors with a body mass index ≥25 kg/m 2 to a 6-month lifestyle intervention (N = 102) or waitlist group (N = 103). Effects of the intervention on self-reported body weight, physical activity (PA), diet quality (via Health Eating Index—2010 (HEI-2010)), and quality of life were assessed using mixed model repeated measures analysis. Results: At 6 months, the intervention arm had significantly greater weight loss compared with the waitlist group (mean difference = −1.3 kg, 95% confidence interval [CI] = −2.5, −0.13). We observed suggestive improvements in PA (mean difference = 18.7 min/week, 95% CI = −24.2, 61.6), diet quality (mean difference in HEI = 3.2 points, 95% CI = −0.20, 6.5), and fatigue (mean difference in Functional Assessment of Chronic Illness Therapy—Fatigue scale = 1.4 points, 95% CI = −1.1, 3.9). Conclusions: The LEAN Self-Guided intervention led to favorable weight changes over 6 months. Low-resource-intensive programs have the potential to be delivered in diverse healthcare settings and may support breast cancer survivors in achieving a healthy body weight. Keywords: obesity, weight loss program, lifestyle intervention, diet quality, nutrition, physical activity, exercise, breast cancer, survivorship

CITATION EXPORT

Leah S Puklin, Maura Harrigan, Brenda Cartmel et al.. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers. (2023). https://doi.org/10.3390/cancers15194719

AUTHORS

11 · 3 CENTRES

Leah S Puklin, Maura Harrigan, Brenda Cartmel, Tara Sanft, Linda Gottlieb, Bin Zhou, Leah M Ferrucci, Fang-Yong Li, Donna Spiegelman, Mona Sharifi, Melinda L Irwin

1Yale School of Public Health, Yale University, New Haven, CT 06510, USA; [email protected] (L.S.P.); [email protected] (L.M.F.); [email protected] (F.-Y.L.);
2Yale Cancer Center, New Haven, CT 06510, USA
3Yale School of Medicine, Yale University, New Haven, CT 06510, USA

Leah S Puklin, Maura Harrigan, Brenda Cartmel et al.. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers. (2023). https://doi.org/10.3390/cancers15194719