Nanoscale Advances · 8 authors, 6 centres
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This narrative review summarizes nanomaterial-based antibacterial strategies as alternatives to combat multidrug-resistant bacteria. It outlines various antibacterial mechanisms and discusses biosafety and scalability challenges for clinical translation.
This narrative review discusses the problem of multidrug-resistant (MDR) bacterial infections and the potential of nanomaterials as nanoantibiotics. It covers the mechanisms of drug resistance generation, introduces various nanomaterials with different antibacterial mechanisms, and reviews their biosafety profiles and challenges for mass production. The review highlights that nanomaterials offer multiple antibacterial mechanisms, tunable spectra, and low resistance probability, but notes biosafety and large-scale manufacturing as major bottlenecks. It concludes by discussing urgent challenges and future perspectives for developing and translating nanoantibiotics as alternatives to traditional antibiotics.
