Pharmaceuticals · 4 authors, 3 centres
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This narrative review synthesizes recent preclinical and clinical studies on botanical extracts and isolated phytocompounds investigated for rosacea management. It concludes that several natural compounds with anti-inflammatory, vasoprotective, antioxidant, and antimicrobial properties show promise for managing rosacea symptoms, particularly erythema and papules.
This narrative review searched PubMed, Google Scholar, Springer, and MDPI for preclinical and clinical studies on botanical compounds for rosacea, covering articles from February to September 2023. The review synthesizes evidence on phytochemicals exhibiting anti-inflammatory, vasoprotective, antioxidant, and antimicrobial properties, reporting that these agents show promise particularly for the primary features of erythema and papules. Some insights into antiangiogenic mechanisms were also discussed, though these data remain poorly reported. The authors note that most existing clinical studies address resolution of specific symptoms rather than the disease as a whole. Key limitations include a small number of clinical and preclinical studies, lack of standardized methods for assessing severity and treatment efficacy, and the fact that most botanical formulations have not been clinically tested. The review concludes that these natural compounds may enhance efficacy and therapeutic compliance for rosacea patients.
