PLOS ONE · 8 authors, 2 centres
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This cross-sectional study of 852 French adults found a significant positive association between higher urinary bisphenol A (BPA) concentration and the prevalence of diabetes or prediabetes, independent of known risk factors. No significant associations were found for urinary bisphenol S (BPS) or bisphenol F (BPF).
The study analyzed data from 852 adults in the Esteban cross-sectional study to examine the relationship between urinary concentrations of bisphenols (BPA, BPS, BPF) and the prevalence of diabetes or prediabetes. No significant associations were found for BPS or BPF. Strengths include using multiple sources to identify diabetes cases and adjusting for dietary intake. Limitations include the cross-sectional design, which prevents causal inference, a single urinary measure of exposure, and the absence of family history data. The authors conclude that while BPA is associated with dysglycemia, prospective studies are needed to establish causality.
