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TL;DR
It describes how elevated glucose leads to reactive oxygen species (ROS) formation, causing neuronal and pericyte cell loss, capillary blockage, and retinal microvascular distortion.
Journal of Clinical Medicine · 3 authors, 1 centre
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It describes how elevated glucose leads to reactive oxygen species (ROS) formation, causing neuronal and pericyte cell loss, capillary blockage, and retinal microvascular distortion.
It describes how elevated glucose leads to reactive oxygen species (ROS) formation, causing neuronal and pericyte cell loss, capillary blockage, and retinal microvascular distortion. The review details the role of protein kinase C-delta (PKC-δ) signaling in pericyte degeneration and the breakdown of the blood-retina barrier (BRB) as a crucial event. These pathways collectively contribute to clinical features such as vascular leakage, inflammation, and neovascularization. Limitations include the need for further research to understand ncRNA mechanisms and develop non-invasive signatures, especially differentiating between type 1 and type 2 diabetes. The review concludes that understanding these mechanisms is essential for developing targeted therapies.