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TL;DR
This is a protocol for a long-term observational cohort study following approximately 5000 children with severe asthma from childhood into adulthood over about 60 years.
BMC Pulmonary Medicine · 3 authors, 3 centres
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This is a protocol for a long-term observational cohort study following approximately 5000 children with severe asthma from childhood into adulthood over about 60 years.
This paper presents the protocol for the RELATE study, an observational cohort study of the Kongsberg cohort. It aims to follow approximately 5000 children with severe asthma who received specialized care in Norway from 1950 to 1979. The methodology involves a comprehensive follow-up examination after an average of 60 years, including questionnaires, blood sampling for biobanking, lung function tests, and analysis of nationwide registry data to assess mortality and socioeconomic status. The authors discuss the rationale, highlighting the potential for early life factors to influence lifelong respiratory health. Key limitations noted include potential selection bias, reliance on historical diagnoses, and issues with data completeness from registries. The study protocol is designed to provide insights into disease trajectories from childhood to end of life.