Relationship between haemodynamic indicators and haemogram in patients with heart failure

ESC Heart Failure · 7 authors, 1 centre

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This retrospective study of 345 heart failure patients used statistical modeling to find that elevated left ventricular end-diastolic pressure (LVEDP) was significantly associated with a lower platelet count, suggesting lung pressure overload may affect platelet production.

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A retrospective analysis included 345 patients who underwent cardiac catheterization. The central finding was a significant negative relationship between LVEDP and platelet count (standardized estimate: −0.129, P = 0.015). Significant positive relationships were also found between plasma noradrenaline and both WBC and platelet counts. A positive relationship existed between eGFR and haemoglobin level. Bayesian inference supported the negative link between LVEDP and platelet count. The results suggest hemodynamic factors are related to haemogram parameters in heart failure, with a specific link between lung pressure overload and reduced platelet count.

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cohort

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cardiology

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ORIGINAL PAPER

PMC10053360

Relationship between haemodynamic indicators and haemogram in patients with heart failure

ESC Heart Failure

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ABSTRACT

Abstract Aims Pulmonary congestion, reduced cardiac output, neurohumoral factor activation, and decreased renal function associated with decreased cardiac function may have various effects on haemograms. The relationship between these factors and haemograms in patients with heart failure has not been sufficiently investigated. Recently, it was suggested that the lungs are an important site for platelet (Plt) biosynthesis and that it is necessary to study the relationship between pulmonary congestion and Plt count in heart failure in detail. In this study, we examined the relationship between various haemodynamic indicators and haemograms in detail using statistical analyses. Methods and results A total of 345 patients who underwent cardiac catheterization for the evaluation of cardiac function between 1 January 2015 and 31 December 2020 were included in the study. Haemodynamic indices, including left ventricular end‐diastolic pressure (LVEDP) and cardiac index (CI), were measured. Plasma noradrenaline (Nor) concentration, estimated glomerular filtration rate (eGFR), white blood cell (WBC) count, haemoglobin (Hb) level, and Plt count were measured using blood samples collected at the same time. Structural equation modelling (SEM) was used to examine the relationship between LVEDP, CI, plasma Nor concentration, eGFR, WBC count, Hb level, and Plt count. Bayesian inference using SEM was performed for Plt count. A total of 345 patients (mean age: 66.0 ± 13.2 years) were included in this study, and 251 (73%) patients were men. After simple and multiple regression analyses, path diagrams were drawn and analysed using SEM. LVEDP showed a significant negative relationship with Plt count (standardized estimate: −0.129, P = 0.015), and CI showed a significant negative relationship with Hb level (standardized estimate: −0.263, P < 0.001). Plasma Nor concentration showed a significant positive relationship with WBC count (standardized estimate: 0.165, P = 0.003) and Plt count (standardized estimate: 0.198, P < 0.001). The eGFR had a significant positive relationship with Hb level (standardized estimate: 0.274, P < 0.001). Bayesian inference using SEM revealed no relationship between LVEDP and Hb level or WBC count but a significant negative relationship between LVEDP and Plt count. Conclusions LVEDP, CI, plasma Nor concentration, and eGFR were related to WBC count, Hb level, and Plt count in patients with heart failure. There was a strong relationship between elevated LVEDP and decreased Plt count, suggesting that pressure overload on the lungs may interfere with the function of the lung as a site of Plt biosynthesis.

CITATION EXPORT

Takuya Oh, Kazuo Ogawa, Tomohisa Nagoshi et al.. Relationship between haemodynamic indicators and haemogram in patients with heart failure. ESC Heart Failure. (2022). https://doi.org/10.1002/ehf2.14258

AUTHORS

7 · 1 CENTRES

Takuya Oh, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura

1 Division of Cardiology, Department of Internal Medicine The Jikei University School of Medicine 3‐25‐8 Nishi‐shinbashi, Minato‐ku Tokyo 105‐8461 Japan