SEARCHNARRATIVE_REVIEWgastroenterology, hematology

narrative_review·gastroenterology, hematology, internal medicine, preclinical research·PMC10019217

Relationship between iron overload caused by abnormal hepcidin expression and liver disease: A review

Medicine · 7 authors, 3 centres

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TL;DR

It links hepcidin dysregulation to conditions like hepatitis, cirrhosis, and hepatocellular carcinoma (HCC).

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108 CHARS

It links hepcidin dysregulation to conditions like hepatitis, cirrhosis, and hepatocellular carcinoma (HCC).

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narrative_review

SPECIALTY

gastroenterology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10019217

Relationship between iron overload caused by abnormal hepcidin expression and liver disease: A review

Medicine

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ABSTRACT

Abstract Iron is essential to organisms, the liver plays a vital role in its storage. Under pathological conditions, iron uptake by the intestine or hepatocytes increases, allowing excess iron to accumulate in liver cells. When the expression of hepcidin is abnormal, iron homeostasis in humans cannot be regulated, and resulting in iron overload. Hepcidin also regulates the release of iron from siderophores, thereby regulating the concentration of iron in plasma. Important factors related to hepcidin and systemic iron homeostasis include plasma iron concentration, body iron storage, infection, inflammation, and erythropoietin. This review summarizes the mechanism and regulation of iron overload caused by hepcidin, as well as related liver diseases caused by iron overload and treatment. Keywords: hepcidin, homeostasis, iron overload, liver disease

CITATION EXPORT

Haoran Zheng, Fan Yang, Kaige Deng et al.. Relationship between iron overload caused by abnormal hepcidin expression and liver disease: A review. Medicine. (2023). https://doi.org/10.1097/MD.0000000000033225

AUTHORS

7 · 3 CENTRES

Haoran Zheng, Fan Yang, Kaige Deng, Jiaxin Wei, Zhenting Liu, Yong-Chang Zheng, Haifeng Xu

a Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of China
b Division of Liver Surgery, Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
c Department of Emergency, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.