Antibiotics · 7 authors, 4 centres
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This retrospective study analyzed VigiBase data to describe trends in antimicrobial-related adverse drug events (ADEs) reported in Jordan from 2003 to 2022. The central finding was a significant increase in reporting from 2019 onward, attributed to enhanced pharmacovigilance activities and policy changes.
This retrospective study analyzed individual case safety reports (ICSRs) from the VigiBase database for antimicrobial-related adverse drug events (ADEs) reported in Jordan between 2003 and 2022. The study describes reporting trends, the most commonly reported antimicrobial drug classes and system organ classes (SOCs) for ADEs, and the relationship with WHO AWaRe categories. Tetracyclines, fluoroquinolones, and third-generation cephalosporins were the most frequently reported antimicrobial classes. Skin and subcutaneous tissue disorders, general disorders, and gastrointestinal disorders were the most common SOCs. Limitations include incomplete data on reporter characteristics, ADE seriousness, and causality for deaths. The findings provide a baseline for understanding antimicrobial ADE reporting patterns in Jordan and highlight the impact of national pharmacovigilance initiatives.
