Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses

Heliyon · 9 authors, 4 centres

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TL;DR

It found that research has shifted from general TRPV1 studies to focus on its structure and roles in diseases like pain, cancer, and neurodegenerative conditions.

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The primary research area was neuroscience, with the United States as the leading publishing country. Analysis of keywords indicates an initial broad study of TRPV1, with recent research focusing on TRPV1 structure and its involvement in diseases. The analysis concludes that TRPV1 disease research centers on pain, cancer, and neurodegenerative diseases, and that both agonists and antagonists are moving toward clinical use.

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other

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biomedical research

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ORIGINAL PAPER

PMC10827456

Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses

Heliyon

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ABSTRACT

Abstract Background Transient receptor potential vanilloid type1 (TRPV1) is a non-selective cation channel with multiple activation mechanisms, which has received increasing attention since it was first cloned in 1997. Methods We used bibliometric and visualization analyses to evaluate the theme trends and knowledge structure of TRPV1 research-papers on TRPV1 from 2002 to 2022 obtained from the Web of Science Core Collection. VOSviewer and CiteSpace were used to analyze authors, institutions, countries, co-cited references, and keywords. Results A total of 7413 papers were included. The main research area of TRPV1 was neuroscience; the most published country was the United States, and the University of California, San Francisco, had the highest centrality. Two major collaborative sub-networks were formed between the authors. The distribution of keywords shows that TRPV1 was initially studied extensively, and the recent studies focused on TRPV1 structure and diseases. “Oxidative stress,” “TRPV1 structure,” “cancer,” and “model” have been the research hotspots in recent years. Conclusions This research provides valuable information for the study of TRPV1. Disease research was focused on pain, cancer, and neurodegenerative diseases. Both agonists and antagonists of TRPV1 are gradually being used in clinical practice, and acupuncture was effective in treating TRPV1-mediated inflammatory pain. TRPV1 is involved in classical endogenous cannabis system signaling, and new signaling pathways continue to be revealed. Keywords: TRPV1, Bibliometrics, Visualization analyses, Research hotspots, CiteSpace

CITATION EXPORT

Jingchun Zeng, Yiqian Lu, Hui Chu et al.. Research trends and frontier hotspots of TRPV1 based on bibliometric and visualization analyses. Heliyon. (2024). https://doi.org/10.1016/j.heliyon.2024.e24153

AUTHORS

9 · 4 CENTRES

Jingchun Zeng, Yiqian Lu, Hui Chu, Liming Lu, Yuexuan Chen, Kaisong Ji, Yeze Lin, Jingjing Li, Shuxin Wang

aRehabilitation Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
bThe First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
cClinical Research and Data Center, South China Research Center for Acupuncture and Moxibustion, Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
dBao'an Traditional Chinese Medicine Hospital//Seventh Clinical Medical College of Guangzhou University of Traditional Chinese Medicine, Shenzhen, Guangdong, China