Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization

iScience · 10 authors, 6 centres

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FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

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TL;DR

This preclinical study in mice showed that restoring normal blood flow by removing an atherosclerosis-inducing cuff led to plaque stabilization, a benefit comparable to the drug atorvastatin.

Full summary

257 CHARS

The cuff was then either maintained or removed to restore normal blood flow for a four-week therapeutic period. The therapeutic benefit of restoring normal blood flow was comparable to treatment with atorvastatin, and the combination had an additive effect.

STUDY TYPE

other

SPECIALTY

cardiology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10206490

Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization

iScience

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ABSTRACT

Summary Blood flow is a key regulator of atherosclerosis. Disturbed blood flow promotes atherosclerotic plaque development, whereas normal blood flow protects against plaque development. We hypothesized that normal blood flow is also therapeutic, if it were able to be restored within atherosclerotic arteries. Apolipoprotein E-deficient (ApoE −/− ) mice were initially instrumented with a blood flow-modifying cuff to induce plaque development and then five weeks later the cuff was removed to allow restoration of normal blood flow. Plaques in decuffed mice exhibited compositional changes that indicated increased stability compared to plaques in mice with the cuff maintained. The therapeutic benefit of decuffing was comparable to atorvastatin and the combination had an additive effect. In addition, decuffing allowed restoration of lumen area, blood velocity, and wall shear stress to near baseline values, indicating restoration of normal blood flow. Our findings demonstrate that the mechanical effects of normal blood flow on atherosclerotic plaques promote stabilization.

CITATION EXPORT

Morgan A. Schake, Ian S. McCue, Evan T. Curtis et al.. Restoration of normal blood flow in atherosclerotic arteries promotes plaque stabilization. iScience. (2023). https://doi.org/10.1016/j.isci.2023.106760

AUTHORS

10 · 6 CENTRES

Morgan A. Schake, Ian S. McCue, Evan T. Curtis, Thomas J. Ripperda, Samuel Harvey, Bryan T. Hackfort, Anna Fitzwater, Yiannis S. Chatzizisis, Forrest M. Kievit, Ryan M. Pedrigi

1Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
2Department of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USA
3Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
4Institutional Animal Care Program, University of Nebraska-Lincoln, Lincoln, NE 68583, USA
5Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
6Nebraska Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, NE 68588, USA