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TL;DR
In a cross-sectional study of 108 individuals, reticulocyte hemoglobin (Ret-Hb) was significantly decreased in iron deficiency anemia patients, and a cut-off of 21.2 pg yielded 100% sensitivity and 64.1% specificity for predicting IDA.
Hematology Reports · 8 authors, 6 centres
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In a cross-sectional study of 108 individuals, reticulocyte hemoglobin (Ret-Hb) was significantly decreased in iron deficiency anemia patients, and a cut-off of 21.2 pg yielded 100% sensitivity and 64.1% specificity for predicting IDA.
This cross-sectional study of 108 individuals compared hematologic parameters including Ret-Hb between 64 IDA patients and 44 non-anemic controls at Najran University Hospital. All participants underwent CBC, reticulocyte percentage, Ret-Hb, serum iron, TIBC, and ferritin measurements. Ret-Hb was significantly decreased in IDA patients of both sexes compared to healthy controls (p = 0.0001). A Ret-Hb cut-off of 21.2 pg was identified with 100% sensitivity and 64.1% specificity for predicting IDA. Ret-Hb correlated positively with hemoglobin (r = 0.819, p = 0.0001) and ferritin (r = 0.540, p = 0.0001). In non-anemic individuals, Ret-Hb was significantly decreased in males with low ferritin, while females showed only a non-significant tendency to decrease. Limitations include the small single-center sample and exclusion of pregnant women and patients with chronic diseases.