Risk Assessment Considering the Bioavailability of 3-β- d -Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea

Toxins · 5 authors, 2 centres

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AGENT 01 · STRUCTURED SUMMARY

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TL;DR

This study used occurrence data from 537 cereal and legume samples in Korea and literature-based bioavailability estimates to model dietary exposure to type B trichothecene mycotoxins and their glucoside conjugates under three scenarios. The TDI% for both DON and NIV groups remained at a safe level, not exceeding 100%, though infants showed higher TDI% than adults for both toxin groups.

Full summary

891 CHARS

This risk assessment evaluated human dietary exposure to type B trichothecene mycotoxins (DON, NIV) and their glucoside conjugates (DON3G, NIV3G) in the Korean food supply. Occurrence data from 537 cereals, legumes, and their products were analyzed using literature-based bioavailability estimates for glucoside conjugates under three exposure scenarios. The TDI% for both the DON and NIV groups did not exceed 100%, indicating a safe level. The TDI% of the NIV group was about 2–3 times higher than that of the DON group. Infants showed a higher TDI% than adults for both toxin groups. TDI% by food processing type tended to decrease in the order of raw material > simply processed > fermented processed. A key limitation is that the bioavailability of glucoside conjugates was based on insufficient previous studies, and occurrence data covered only a small number of glucoside conjugates.

STUDY TYPE

other

SPECIALTY

food science

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10467052

Risk Assessment Considering the Bioavailability of 3-β- d -Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea

Toxins

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ABSTRACT

Abstract Deoxynivalenol and nivalenol are major type B trichothecenes and the most frequently occurring mycotoxins worldwide. Their 3-β- d -glucoside forms have recently become a safety management issue. These glucoside conjugates are converted back to the parent toxins during human digestion, but studies to confirm their bioavailability are lacking. In this study, a risk assessment was performed considering the bioavailability of glucoside conjugates. A literature review was conducted to compile the existing bioavailability studies of glucoside conjugates, and three exposure scenarios considering bioavailability were established. As a result of a risk assessment using deterministic and probabilistic methods, both the deoxynivalenol and nivalenol groups had safe levels of tolerable daily intake percentage (TDI%), not exceeding 100%. The TDI% for the nivalenol group was approximately 2–3 times higher than that for the deoxynivalenol group. Notably, infants showed higher TDI% than adults for both toxin groups. By food processing type, the overall TDI% was highest for raw material, followed by simple-processed and then fermented-processed. Since glucoside conjugates can be converted into parent toxins during the digestion process, a risk assessment considering bioavailability allows the more accurate evaluation of the risk level of glucoside conjugates and can direct their safety management in the future. Keywords: type B trichothecene, modified mycotoxin, exposure, glucoside conjugate

CITATION EXPORT

Sang Yoo Lee, Solyi Cho, So Young Woo et al.. Risk Assessment Considering the Bioavailability of 3-β-d-Glucosides of Deoxynivalenol and Nivalenol through Food Intake in Korea. Toxins. (2023). https://doi.org/10.3390/toxins15070460

AUTHORS

5 · 2 CENTRES

Sang Yoo Lee, Solyi Cho, So Young Woo, Myungsil Hwang, Hyang Sook Chun

1Food Toxicology Laboratory, School of Food Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea; [email protected] (S.Y.L.); [email protected] (S.C.); [email protected] (S.Y.W.)
2Department of Food & Nutrition, Gachon University, Incheon 21936, Republic of Korea; [email protected]