Chinese Medical Journal · 6 authors, 4 centres
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This narrative review describes how adipokines like leptin and adiponectin may regulate muscle mass and function in the context of sarcopenia. The authors propose that these factors could serve as potential biomarkers or therapeutic targets for the age-related muscle disease.
This narrative review examines the potential roles of adipokines, hormones secreted by adipose tissue, in the pathogenesis of sarcopenia, an age-related loss of muscle mass and function. The authors synthesize existing preclinical and clinical evidence to describe how specific adipokines, including leptin, adiponectin, resistin, visfatin, and lipocalin-2, may influence muscle biology. Central results suggest that higher serum leptin levels are associated with decreased muscle function, while adiponectin may inhibit muscle atrophy-related genes. The review concludes that these adipokines are related to sarcopenia and could be explored as potential biomarkers for early detection or as novel therapeutic targets. The implications are that further clinical and preclinical studies are needed to clarify these roles and explore clinical applications.
