Molecular and Cellular Biochemistry · 3 authors, 1 centre
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This is a narrative review that discusses how sirtuins (SIRTs) are involved in molecular pathways related to inflammation, oxidative stress, and plaque development in atherosclerosis. The central result is that sirtuins represent a potential novel therapeutic target to stabilize plaques and reduce cardiovascular events, based on a synthesis of existing literature.
This narrative review synthesizes existing literature on the role of sirtuins (SIRTs) in the pathogenesis of atherosclerosis and plaque vulnerability. It describes the molecular mechanisms through which SIRTs regulate oxidative stress, inflammation, and cellular aging, processes that are implicated in plaque progression and rupture. The review discusses the potential of targeting SIRTs with activators and modulators as a novel therapeutic strategy to attenuate plaque formation and vulnerability, complementing traditional statin therapy. A key limitation noted is the scarcity of literature specifically examining SIRTs in relation to plaque vulnerability, warranting further investigation.
