SEARCHCOHORTpediatrics, infectious disease

cohort·pediatrics, infectious disease, immunology, surgery, observational study·PMC10570873

Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients

JAMA Network Open · 59 authors, 22 centres

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TL;DR

This was a multicenter cohort study of 281 pediatric liver and kidney transplant recipients from 18 US transplant centers.

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This was a multicenter cohort study of 281 pediatric liver and kidney transplant recipients from 18 US transplant centers. The primary outcome was the development of seroprotective antibodies following vaccination. Results showed no serious adverse events were observed, with 72% achieving varicella seroprotection, 86% measles, 83% mumps, and 99% rubella. The findings suggest live vaccination can be a safe and immunogenic intervention for select pediatric transplant recipients, potentially allowing for broader eligibility criteria.

STUDY TYPE

cohort

SPECIALTY

pediatrics

SUMMARISED BY

AI pipeline

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100% · A

ORIGINAL PAPER

PMC10570873

Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients

JAMA Network Open

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ABSTRACT

Key Points Question What are the safety and immunogenicity of live vaccines (measles-mumps-rubella and varicella-zoster virus) in select pediatric solid organ transplant recipients? Findings In this cohort study of 281 pediatric liver and kidney transplant recipients from 18 US transplant centers, no serious adverse events were observed following live vaccination, with the majority of children developing protective antibodies (72% varicella, 86% measles, 83% mumps, and 99% rubella). Meaning These findings suggest that administration of live vaccines to select transplant recipients can offer seroprotection against the ongoing risk of exposure to circulating measles, mumps, and varicella.

CITATION EXPORT

Amy G Feldman, Brenda L Beaty, Jose A Ferrolino et al.. Safety and Immunogenicity of Live Viral Vaccines in a Multicenter Cohort of Pediatric Transplant Recipients. JAMA Network Open. (2023). https://doi.org/10.1001/jamanetworkopen.2023.37602

AUTHORS

59 · 22 CENTRES

Amy G Feldman, Brenda L Beaty, Jose A Ferrolino, Gabriela Maron, Hillary K Weidner, Saira A Ali, Leandra Bitterfeld, Mary Alice Boulware, Kathleen M Campbell, Emily Carr, Shelley Chapman, Yeh-Chung Chang, Ryan Cunningham, Ronald H Dallas, Keerti L Dantuluri, Bryanna N Domenick, Noelle H Ebel, Scott Elisofon, Rima Fawaz, Marc Foca, Hayley A Gans, Vani V Gopalareddy, Cindy Gu, Nitika A Gupta, Katherine Harmann, Jessica Hollenbeck, Anna R Huppler, Catalina Jaramillo, Nagraj Kasi, Nanda Kerkar, Stacee Lerret, Steven J Lobritto, Maclovio J Lopez, Elizabeth Marini, Alisha Mavis, Sonia Mehra, Lynnette Moats, Sindhu Mohandas, Flor M Munoz, Krupa R Mysore, Ceren Onsan, Nadia Ovchinsky, Kerrigan Perkins, Stacy Postma, Lauren Pratscher, Elizabeth B Rand, Regina K Rowe, Danielle Schultz, Katherine Sear, Megan L Sell, Tanvi Sharma, Janis Stoll, Mychoua Vang, Dominique Villarin, Carly Weaver, Phoebe Wood, Olivia Woodford-Berry, George Yanni, Lara A Danziger-Isakov

1Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado and Children’s Hospital Colorado, Aurora
2Adult & Child Center for Outcomes Research & Delivery Science (ACCORDS), University of Colorado and Children’s Hospital Colorado, Aurora
3Department of Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee
4Cincinnati Children’s Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio
5Emory University School of Medicine, Children’s Healthcare of Atlanta, Atlanta, Georgia
6Intermountain Primary Children’s Hospital, Salt Lake City, Utah
7Levine Children’s Hospital at Atrium Health, Charlotte, North Carolina
8Yale University, New Haven, Connecticut
9Children’s Wisconsin, Medical College of Wisconsin, Milwaukee
10Duke University Medical Center, Durham, North Carolina
11NYU Grossman School of Medicine, New York, New York
12Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
13Lucile Packard Children’s Hospital at Stanford, Palo Alto, California
14Boston Children’s Hospital, Boston, Massachusetts
15Albert Einstein College of Medicine, Children’s Hospital at Montefiore, Bronx, New York
16Golisano Children’s Hospital at Strong, University of Rochester Medical Center, Rochester, New York
17C.S. Mott Children’s Hospital, Michigan Medicine, Ann Arbor
18Medical University of South Carolina Shawn Jenkins Children’s Hospital, Charleston
19Children’s Hospital of New York, NewYork-Presbyterian Hospital, New York
20Children’s Hospital Los Angeles, Los Angeles, California
21Texan Children’s Hospital, Baylor College of Medicine, Houston, Texas
22Washington University School of Medicine, St Louis, Missouri