Scientific Reports · 4 authors, 1 centre
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This nationwide Korean survey of 11,533 participants investigated the link between sarcopenia and age-related eyelid drooping. The study found that individuals with sarcopenia, defined by low muscle mass relative to body size, had a significantly higher prevalence of senile blepharoptosis.
This cross-sectional study used data from a nationwide representative Korean survey (KNHANES 2008–2011) to examine the association between sarcopenia and senile blepharoptosis in 11,533 participants. Sarcopenia was defined using a body mass index (BMI)-adjusted muscle mass index (MMI) derived from appendicular skeletal muscle mass. Multivariate logistic regression analysis showed that sarcopenia, defined as the lowest MMI quintile, was significantly associated with a higher prevalence of blepharoptosis (adjusted OR 1.18, 95% CI 1.04–1.34). Furthermore, MMI showed a proportional relationship with eyelid levator muscle function. The study is limited by its cross-sectional design, which cannot establish causality, and its data being restricted to the Korean population. The findings suggest sarcopenia is an independent risk factor for senile blepharoptosis, potentially through age-related muscle degeneration affecting the levator palpebrae superioris muscle.
