SEARCHCOHORTcritical care, pulmonology

cohort·critical care, pulmonology, infectious disease, epidemiology, clinical trial·PMC10123590

SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone

Scientific Reports · 19 authors, 18 centres

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This prospective multicentre observational cohort study enrolled 259 mechanically ventilated COVID-19 patients from 11 ICUs in the Greater Paris area between October 1, 2020, and May 30, 2021, with full-length SARS-CoV-2 genome sequencing performed on nasopharyngeal samples. The authors acknowledge limited statistical power and that findings do not generalize to Delta or Omicron variants, suggesting VAP in critically ill COVID-19 patients is driven by non-virological causes.

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cohort

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critical care

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ORIGINAL PAPER

PMC10123590

SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone

Scientific Reports

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ABSTRACT

We aimed to explore the relationships between specific viral mutations/mutational patterns and ventilator-associated pneumonia (VAP) occurrence in COVID-19 patients admitted in intensive care units between October 1, 2020, and May 30, 2021. Full-length SARS-CoV-2 genomes were sequenced by means of next-generation sequencing. In this prospective multicentre cohort study, 259 patients were included. 222 patients (47%) had been infected with pre-existing ancestral variants, 116 (45%) with variant α, and 21 (8%) with other variants. 153 patients (59%) developed at least one VAP. There was no significant relationship between VAP occurrence and a specific SARS CoV-2 lineage/sublineage or mutational pattern.

CITATION EXPORT

Keyvan Razazi, Anissa Martins Bexiga, Romain Arrestier et al.. SARS-CoV-2 variants and mutational patterns: relationship with risk of ventilator-associated pneumonia in critically ill COVID-19 patients in the era of dexamethasone. Scientific Reports. (2023). https://doi.org/10.1038/s41598-023-33639-5

AUTHORS

19 · 18 CENTRES

Keyvan Razazi, Anissa Martins Bexiga, Romain Arrestier, Bastien Peiffer, Guillaume Voiriot, Charles-Edouard Luyt, Tomas Urbina, Julien Mayaux, Tài Pham, Damien Roux, Raphael Bellaiche, Zakaria AIt Hamou, Stéphane Gaudry, Elie Azoulay, Armand Mekontso Dessap, Christophe Rodriguez, Jean-Michel Pawlotsky, Slim Fourati, Nicolas de Prost

1grid.412116.10000 0004 1799 3934Médecine Intensive Réanimation, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), 51, Av de Lattre de Tassigny, 94000 Créteil Cedex, France
2grid.410511.00000 0001 2149 7878Groupe de Recherche Clinique CARMAS, Université Paris-Est-Créteil (UPEC), Créteil, France
3grid.410511.00000 0001 2149 7878Université Paris-Est-Créteil (UPEC), Créteil, France
4grid.412116.10000 0004 1799 3934DMU Medecine, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris (AP-HP), Créteil, France
5grid.50550.350000 0001 2175 4109Médecine Intensive Réanimation, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France
6grid.411439.a0000 0001 2150 9058Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, and INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Paris, France
7grid.462844.80000 0001 2308 1657Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Saint-Antoine, Médecine Intensive Réanimation, 75571 Paris Cedex 12, France
8grid.411439.a0000 0001 2150 9058Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Médecine Intensive Réanimation, Paris, France
9grid.413784.d0000 0001 2181 7253Service de Médecine Intensive-Réanimation, Assistance Publique-Hôpitaux de Paris, Hôpital de Bicêtre, DMU 4 CORREVE Maladies du Cœur et des Vaisseaux, FHU Sepsis, Le Kremlin-Bicêtre, France
10grid.463845.80000 0004 0638 6872Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm U1018, Equipe d’Epidémiologie Respiratoire Intégrative, CESP, 94807 Villejuif, France
11grid.414205.60000 0001 0273 556XUniversité de Paris, APHP, Hôpital Louis Mourier, DMU ESPRIT, Service de Médecine Intensive Réanimation, Colombes, France
12grid.465541.70000 0004 7870 0410Department of Immunology, Infectiology and Hematology, INSERM U1151, CNRS UMR 8253, Institut Necker-Enfants Malades (INEM), Colombes, Paris, France
13grid.412116.10000 0004 1799 3934Département d’Anesthésie Réanimations Chirurgicales, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France
14grid.411784.f0000 0001 0274 3893Médecine Intensive Réanimation, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France
15grid.413780.90000 0000 8715 2621Service de Réanimation, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, France
16grid.413328.f0000 0001 2300 6614Médecine Intensive Réanimation, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France
17grid.412116.10000 0004 1799 3934Department of Virology, Hôpitaux Universitaires Henri Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, France
18grid.462410.50000 0004 0386 3258INSERM U955, Team «Viruses, Hepatology, Cancer», Créteil, France