other·nutrition, public health, systematic review, meta-analysis, research methods·PMC10012519
Saturated fat and human health: a protocol for a methodologically innovative systematic review and meta-analysis to inform public health nutrition guidelines
Systematic Reviews · 25 authors, 25 centres
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FIDELITY 100%
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This is a protocol for a planned systematic review and meta-analysis of randomized controlled trials on modifying saturated fat intake and its effect on health outcomes. No empirical findings are reported; the paper outlines the methodology to be used for future evidence synthesis.
Full summary
889 CHARS
This paper is a protocol for a systematic review and meta-analysis. The authors plan to search for randomized clinical trials (RCTs) assessing the reduction or replacement of saturated fat with other fats, carbohydrates, or protein. The primary methodology involves duplicate screening and data extraction, risk of bias assessment using rigorous criteria, and meta-analysis. A key methodological focus is on handling missing participant outcome data through sensitivity analyses using specified event rate ratios (1.5:1, 2:1, 3:1, and 5:1). The protocol will use the GRADE approach to assess the certainty of evidence for each outcome. The review aims to provide a comprehensive summary to inform public health nutrition guidelines. As a protocol, it describes planned methods and does not present results, so implications are limited to the future application of its designed methodology.
