Serum Amyloid A 4 as a Common Marker of Persistent Inflammation in Patients with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy

Journal of Inflammation Research · 5 authors, 2 centres

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This study used liquid chromatography-tandem mass spectrometry to compare the aqueous humor proteomes of patients with nAMD, PCV, and control subjects.

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This study used liquid chromatography-tandem mass spectrometry to compare the aqueous humor proteomes of patients with nAMD, PCV, and control subjects. A total of 737 proteins were identified, with 544 quantifiable. The study concludes that immune response activation is central to both nAMD and PCV pathogenesis, and SAA4 alteration may represent a common biomarker. Limitations include the small sample size, particularly for PCV, necessitating confirmation in larger studies.

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other

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ophthalmology

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ORIGINAL PAPER

PMC10474861

Serum Amyloid A 4 as a Common Marker of Persistent Inflammation in Patients with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy

Journal of Inflammation Research

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ABSTRACT

Abstract Background Neovascular age-related macular degeneration (nAMD) and its subtype, polypoidal choroidal vasculopathy (PCV), are common choroidal vasculopathies. Although they share many common clinical manifestations and treatment strategies, a lack of comprehensive analysis of these conditions means that it is difficult for researchers to further explore the common pathomechanisms of nAMD and PCV. The aim of this study was to characterize aqueous humor (AH) proteome alterations and identify a novel biomarker related to both nAMD and PCV. Methods Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) was adopted to analyze the AH proteomes of nAMD, PCV and controls. The target protein was validated using the enzyme-linked immunosorbent assay (ELISA) and subjected to receiver operating characteristic (ROC) curve analysis. Results A total of 737 different proteins were identified in all the groups, of which 544 were quantifiable. The bioinformatics analysis suggested that immune response activation is the essential event in both nAMD and PCV. Serum amyloid A (SAA) 4 is closely associated with a number of chronic inflammatory diseases, and it was enriched as the hub protein. ROC analysis showed that SAA4 could distinguish both nAMD and PCV from the controls. Conclusion This comprehensive study provides insights into, and furthers our understanding of, the pathological mechanism of nAMD and PCV. Additionally, the SAA4 level alteration may serve as a common biomarker of nAMD and PCV. Keywords: serum amyloid A 4, inflammation, neovascular age-related macular degeneration, polypoidal choroidal vasculopathy

CITATION EXPORT

Qingyan Liu, Shuo Sun, Zhengwei Yang et al.. Serum Amyloid A 4 as a Common Marker of Persistent Inflammation in Patients with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy. Journal of Inflammation Research. (2023). https://doi.org/10.2147/JIR.S417791

AUTHORS

5 · 2 CENTRES

Qingyan Liu, Shuo Sun, Zhengwei Yang, Yan Shao, Xiaorong Li

1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, People’s Republic of China
2Department of Ophthalmology, Anhui NO.2 Provincial People’s hospital, Hefei, 230041, People’s Republic of China