cohort·cardiology, epidemiology, public health, observational study·PMC10584119
Sex differences in risk factors for incident peripheral artery disease hospitalisation or death: Cohort study of UK Biobank participants
PLOS ONE · 10 authors, 8 centres
AI SUMMARY
FIDELITY 100%
POPULATION500,207 UK Biobank participants (54.5% women, mean age 56.5 years) without prior hospitalisation of PAD at baseline.
INTERVENTIONAssessment of baseline risk factors including blood pressure, smoking, diabetes, lipids, adiposity, history of stroke or MI, socioeconomic status, kidney function, C-reactive protein, and alcohol consumption.
COMPARISONSex-specific comparisons of risk factor associations with PAD incidence (women vs. men).
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
The study found that while PAD incidence was higher in men, smoking and a history of stroke or MI were more strongly associated with a higher risk of PAD in women than men.
Full summary
882 CHARS
This prospective cohort study used UK Biobank data to examine sex differences in risk factors for incident peripheral artery disease (PAD) hospitalisation or death. Age-adjusted incidence rates were higher in men. Most risk factors were associated with higher PAD risk in both sexes. Key findings include that compared to men, women who smoked had an 18% greater excess risk, those with a history of stroke had a 26% greater excess risk, and those with a history of myocardial infarction (MI) had a 50% greater excess risk. Higher high-density lipoprotein cholesterol (HDL-C) was more strongly associated with lower PAD risk in women, with a 34% greater relative reduction per 1 mmol/L increase. The lowest HDL-C level (≤40 mg/dL) was associated with a greater excess risk in women, while the highest level (>80 mg/dL) was associated with lower risk in women but higher risk in men.
PICO
PPOPULATION
500,207 UK Biobank participants (54.5% women, mean age 56.5 years) without prior hospitalisation of PAD at baseline.
IINTERVENTION
Assessment of baseline risk factors including blood pressure, smoking, diabetes, lipids, adiposity, history of stroke or MI, socioeconomic status, kidney function, C-reactive protein, and alcohol consumption.
