Frontiers in Medicine · 4 authors, 2 centres
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This cross-sectional study of 2,989 healthy adults found a sex-specific association between serum bicarbonate and uric acid levels. In men, higher bicarbonate levels were linearly linked to lower uric acid levels, while women showed a more complex, bidirectional pattern.
This retrospective cross-sectional study analyzed data from 2,989 healthy Qatari adults from the Qatar Biobank. Researchers examined the sex-specific association between serum bicarbonate and uric acid levels using quartile analyses and restricted cubic spline models. In men, low serum uric acid levels were significantly associated with higher serum bicarbonate quartiles after adjusting for age, BMI, smoking, and renal function. In women, no significant linear association was found using quartile analysis, but a restricted cubic spline method revealed a significant bidirectional relationship, with positive association below 25 mEq/L bicarbonate and negative association above. The findings suggest a potential protective role of bicarbonate against hyperuricemia in men, but underlying mechanisms require further investigation.
