Significant Loss of Macronutrients During Passage Through Feeding Tube: An Observational Study

JPGN Reports · 6 authors, 4 centres

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TL;DR

This laboratory study simulated tube feeding to test if infant formulas lose nutrients after passing through a nasogastric tube. It found that fat, protein, carbohydrate, and energy content significantly decreased in some, but not all, of the tested formulas.

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This observational, preclinical laboratory study evaluated changes in the macronutrient content of 11 infant formulas after simulated passage through a nasogastric tube. Using a closed system with an infusion pump to mimic intermittent bolus feeding, researchers performed 220 measurements, analyzing pre- and post-infusion formula with a mid-infrared spectroscopy analyzer. The central result was that variations in at least one macronutrient (fat, protein, carbohydrate, or energy) were observed in 5 out of the 10 formulas analyzed after excluding one for technical error. The implications are that nutrient loss during tube feeding is possible and may be formula-specific, warranting further research to understand its biological significance for very low birth weight infants.

STUDY TYPE

other

SPECIALTY

clinical nutrition

SUMMARISED BY

AI pipeline

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ORIGINAL PAPER

PMC10191513

Significant Loss of Macronutrients During Passage Through Feeding Tube: An Observational Study

JPGN Reports

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ABSTRACT

Objective: Feeding infants born before week 34 of gestation is based mainly on providing nutrition directly to the gastrointestinal tract through a nasogastric tube. Little is known about the impact of formulas passage through nasogastric tube on their macronutrient content. The aim of our study was to evaluate changes in macronutrient content of various formulas after transfer through a feeding tube. Methods: Eleven frequently used formulas were chosen. Ten consecutive measurements were performed for each formula. Simulated real-life practice tube feeding was performed by using an infusion pump connected to a feeding tube. A Human Milk Analyzer, using an infrared spectroscopy method, was used to compare the preinfusion and postinfusion macronutrient contents of the different formulas. Results: A total of 220 measurements were performed. Variations in at least one macronutrient were observed in 5 out of 10 formulas. Fat and energy content were modified in 1 preterm formula. Conclusions: Changes in the macronutrient content after tube feeding transfer were observed for some infant formulas, including those designed for very low birth weight infants. These alterations might relate to specific formulation of each formula. The biological significance of our results to the very low birth weight infants should be studied further.

CITATION EXPORT

Hadar Moran-Lev, Muhammad Azaiza, Laurence Mangel et al.. Significant Loss of Macronutrients During Passage Through Feeding Tube: An Observational Study. JPGN Reports. (2020). https://doi.org/10.1097/PG9.0000000000000006

AUTHORS

6 · 4 CENTRES

Hadar Moran-Lev, Muhammad Azaiza, Laurence Mangel, Francis B. Mimouni, Dror Mandel, Ronit Lubetzky

From the Departments of *Pediatrics and
§Neonatology, Dana Dwek Children’s Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
†Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
‡Neonatology, Shaare Zedek Medical Center, Jerusalem, Israel.