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TL;DR
This is a systematic review of genetic studies on antipsychotic-induced akathisia. It found that specific genetic variants (SNPs) in the DRD2 and HTR1B genes were associated with the condition in patients with schizophrenia.
Genes · 10 authors, 8 centres
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This is a systematic review of genetic studies on antipsychotic-induced akathisia. It found that specific genetic variants (SNPs) in the DRD2 and HTR1B genes were associated with the condition in patients with schizophrenia.
The study is a systematic review following PRISMA guidelines, searching literature from 1977 to 2022 to identify genetic predictors of antipsychotic-induced akathisia (AIA) in patients with schizophrenia. From an initial pool of 37 articles, only three met the inclusion criteria. The review found associations between specific single-nucleotide polymorphisms and AIA: the C allele of rs1800498 and the A allele of rs1800497 in the DRD2 gene, and the TT genotype of rs13212041 in the HTR1B gene. The authors highlight significant limitations, including the low quality of the reviewed studies and inconsistent control data. They conclude that clear genetic biomarkers for AIA are not yet established and call for larger, multicenter studies across diverse populations to confirm potential genetic predictors.