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TL;DR
This is a case report of a 12-year-old boy with ulcerative colitis who did not respond to infliximab but achieved mucosal healing after starting sirolimus.
JPGN reports · 3 authors, 4 centres
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This is a case report of a 12-year-old boy with ulcerative colitis who did not respond to infliximab but achieved mucosal healing after starting sirolimus.
This report describes a single pediatric case of infliximab-refractory ulcerative colitis treated with sirolimus. A 12-year-old male with moderately active pancolitis failed to achieve remission on optimized infliximab therapy. He was started on sirolimus with a target trough level of 8 to 10 ng/mL. A follow-up colonoscopy 8 months after sirolimus initiation showed mucosal healing by endoscopy and histology. The patient remained in clinical and biochemical remission for over 17 months. It suggests that sirolimus may be a potential rescue therapy option for anti-TNF refractory pediatric ulcerative colitis, warranting further investigation.