SEARCHNARRATIVE_REVIEWimmunology, infectious disease

narrative_review·immunology, infectious disease, preclinical research, biomedical research·PMC10040548

Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis

Frontiers in Immunology · 8 authors, 3 centres

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These epigenetic changes are linked to the regulation of antimicrobial processes such as autophagy and nitric oxide production.

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These epigenetic changes are linked to the regulation of antimicrobial processes such as autophagy and nitric oxide production.

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narrative_review

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immunology

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ORIGINAL PAPER

PMC10040548

Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis

Frontiers in Immunology

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ABSTRACT

Abstract Macrophages are the preeminent phagocytic cells which control multiple infections. Tuberculosis a leading cause of death in mankind and the causative organism Mycobacterium tuberculosis (MTB) infects and persists in macrophages. Macrophages use reactive oxygen and nitrogen species (ROS/RNS) and autophagy to kill and degrade microbes including MTB. Glucose metabolism regulates the macrophage-mediated antimicrobial mechanisms. Whereas glucose is essential for the growth of cells in immune cells, glucose metabolism and its downsteam metabolic pathways generate key mediators which are essential co-substrates for post-translational modifications of histone proteins, which in turn, epigenetically regulate gene expression. Herein, we describe the role of sirtuins which are NAD + -dependent histone histone/protein deacetylases during the epigenetic regulation of autophagy, the production of ROS/RNS, acetyl-CoA, NAD + , and S-adenosine methionine (SAM), and illustrate the cross-talk between immunometabolism and epigenetics on macrophage activation. We highlight sirtuins as emerging therapeutic targets for modifying immunometabolism to alter macrophage phenotype and antimicrobial function. Keywords: human macrophages, autophagy, glycolysis, metabolism, histone modifications, SIRTUIN

CITATION EXPORT

Kangling Zhang, Mark L Sowers, Ellie I Cherryhomes et al.. Sirtuin-dependent metabolic and epigenetic regulation of macrophages during tuberculosis. Frontiers in Immunology. (2023). https://doi.org/10.3389/fimmu.2023.1121495

AUTHORS

8 · 3 CENTRES

Kangling Zhang, Mark L Sowers, Ellie I Cherryhomes, Vipul K Singh, Abhishek Mishra, Blanca I Restrepo, Arshad Khan, Chinnaswamy Jagannath

1 Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, United States
2 Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, United States
3 University of Texas Health Houston, School of Public Health, Brownsville, TX, United States