JAMA Cardiology · 12 authors, 6 centres
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This cross-sectional study compared skeletal muscle mitochondria from 27 patients with heart failure with preserved ejection fraction (HFpEF) and 45 healthy controls, finding that mitochondrial respiration was markedly reduced in the HFpEF group and associated with poorer exercise capacity.
This cross-sectional study used high-resolution respirometry on vastus lateralis muscle biopsies from 27 older patients with HFpEF and 45 age-matched healthy controls to assess mitochondrial function. The central result was that patients with HFpEF exhibited significantly reduced mitochondrial respiration across multiple measures of oxidative phosphorylation and electron transfer capacity compared to controls. These mitochondrial abnormalities were significantly associated with reduced peak oxygen consumption, 6-minute walk distance, Short Physical Performance Battery score, and leg strength. The authors concluded that skeletal muscle mitochondrial dysfunction is a feature of HFpEF linked to exercise intolerance. Limitations include higher BMI in the HFpEF group and the lack of measured physical activity data, though adjustments for BMI did not alter the primary differences.
