SEARCHNARRATIVE_REVIEWdermatology, antioxidants

narrative_review·dermatology, antioxidants, preclinical research, nutrition, biomedical research·PMC10855854

Skin Protection by Carotenoid Pigments

International Journal of Molecular Sciences · 4 authors, 4 centres

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TL;DR

This narrative review summarizes evidence from in vitro and in vivo studies on the photoprotective role of carotenoid pigments against skin damage from UV, visible, and near-infrared radiation.

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The review highlights carotenoids' established antioxidant and photoprotective properties, supported by both in vitro studies on cell lines and human clinical trials. It notes the challenge of translating in vitro findings due to differences in light sources and carotenoid delivery. While the photoprotective effects are confirmed, the authors point out that recommended intake doses are not yet established by regulatory agencies, and carotenoids remain primarily dietary supplements. The review also discusses future directions, including nanotechnology to improve carotenoid stability and bioavailability.

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narrative_review

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dermatology

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ORIGINAL PAPER

PMC10855854

Skin Protection by Carotenoid Pigments

International Journal of Molecular Sciences

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ABSTRACT

Abstract Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer formation. Natural substances of plant origin, i.e., polyphenols, flavonoids, and photosynthetic pigments, can protect the skin against the effects of radiation, acting not only as photoprotectors like natural filters but as antioxidant and anti-inflammatory remedies, alleviating the effects of photodamage to the skin. Plant-based formulations are gaining popularity as an attractive alternative to synthetic filters. Over the past 20 years, a large number of studies have been published to assess the photoprotective effects of natural plant products, primarily through their antioxidant, antimutagenic, and anti-immunosuppressive activities. This review selects the most important data on skin photodamage and photoprotective efficacy of selected plant carotenoid representatives from in vivo studies on animal models and humans, as well as in vitro experiments performed on fibroblast and keratinocyte cell lines. Recent research on carotenoids associated with lipid nanoparticles, nanoemulsions, liposomes, and micelles is reviewed. The focus was on collecting those nanomaterials that serve to improve the bioavailability and stability of carotenoids as natural antioxidants with photoprotective activity. Keywords: photosynthetic pigments, carotenoids, UV protection, skin photoprotection, skin photodamage, nanoformulations

CITATION EXPORT

Jolanta Flieger, Magdalena Raszewska-Famielec, Elżbieta Radzikowska-Büchner et al.. Skin Protection by Carotenoid Pigments. International Journal of Molecular Sciences. (2024). https://doi.org/10.3390/ijms25031431

AUTHORS

4 · 4 CENTRES

Jolanta Flieger, Magdalena Raszewska-Famielec, Elżbieta Radzikowska-Büchner, Wojciech Flieger

1Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4A, 20-093 Lublin, Poland
2Faculty of Physical Education and Health, University of Physicl Education, Akademicka 2, 21-500 Biała Podlaska, Poland; [email protected]
3Department of Plastic, Reconstructive and Maxillary Surgery, National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137 Street, 02-507 Warszawa, Poland; [email protected]
4Chair and Department of Anatomy, Medical University of Lublin, K. Jaczewskiego 4, 20-090 Lublin, Poland; [email protected]