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TL;DR
Using generalized additive models, a non-linear association was identified with an inflection point at 9.5 hours.
Chinese Medical Journal · 13 authors, 3 centres
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Using generalized additive models, a non-linear association was identified with an inflection point at 9.5 hours.
Using generalized additive models, a non-linear association was identified with an inflection point at 9.5 hours. Piecewise linear regression showed a significant positive association between sleep duration and TT levels for durations above this threshold (β=640.92, 95% CI 380.42–901.42, P<0.001). After adjustment for multiple covariates, long sleep (≥9.5 h) was associated with significantly higher TT levels compared to short sleep (<9.5 h). Subgroup analysis revealed this association was significant only in men with a BMI <25 kg/m² (β=134.98, 95% CI 7.90–262.06, P=0.038), with a significant interaction (P=0.010). Limitations include the cross-sectional design, which precludes causal inference, reliance on self-reported sleep, and the unavailability of free testosterone or sex hormone-binding globulin data. The findings suggest a potential modifiable lifestyle factor, sleep duration, associated with testosterone levels in normal-weight older men.