Solid Lipid Nanoparticles: Applications and Prospects in Cancer Treatment

International Journal of Molecular Sciences · 6 authors, 5 centres

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TL;DR

This narrative review discusses solid lipid nanoparticles (SLNs) as a promising nanotechnology for improving cancer drug delivery, highlighting their ability to overcome physiological barriers and multidrug resistance. It concludes that while SLNs show significant potential, further research is needed to understand their cellular-level biological responses for safer clinical application.

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This narrative review examines solid lipid nanoparticles (SLNs) as advanced drug delivery systems for cancer therapy. The review synthesizes information on SLN development modalities, mechanisms for overcoming biological barriers and multidrug resistance, scale-up potential, and regulatory considerations. Central findings highlight SLNs' versatility in encapsulating both hydrophilic and hydrophobic compounds, their biocompatibility, and their potential for targeted delivery via passive and active mechanisms.

STUDY TYPE

narrative_review

SPECIALTY

oncology

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AI pipeline

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ORIGINAL PAPER

PMC10094605

Solid Lipid Nanoparticles: Applications and Prospects in Cancer Treatment

International Journal of Molecular Sciences

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ABSTRACT

Recent advancements in drug delivery technologies paved a way for improving cancer therapeutics. Nanotechnology emerged as a potential tool in the field of drug delivery, overcoming the challenges of conventional drug delivery systems. In the field of nanotechnology, solid lipid nanoparticles (SLNs) play a vital role with a wide range of diverse applications, namely drug delivery, clinical medicine, and cancer therapeutics. SLNs establish a significant role owing to their ability to encapsulate hydrophilic and hydrophobic compounds, biocompatibility, ease of surface modification, scale-up feasibility, and possibilities of both active and passive targeting to various organs. In cancer therapy, SLNs have emerged as imminent nanocarriers for overcoming physiological barriers and multidrug resistance pathways. However, there is a need for special attention to be paid to further improving the conceptual understanding of the biological responses of SLNs in cancer therapeutics. Hence, further research exploration needs to be focused on the determination of the structure and strength of SLNs at the cellular level, both in vitro and in vivo, to develop potential therapeutics with reduced side effects. The present review addresses the various modalities of SLN development, SLN mechanisms in cancer therapeutics, and the scale-up potential and regulatory considerations of SLN technology. The review extensively focuses on the applications of SLNs in cancer treatment.

CITATION EXPORT

Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran et al.. Solid Lipid Nanoparticles: Applications and Prospects in Cancer Treatment. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms24076199

AUTHORS

6 · 5 CENTRES

Durgaramani Sivadasan, Kalaivanan Ramakrishnan, Janani Mahendran, Hariprasad Ranganathan, Arjunan Karuppaiah, Habibur Rahman

1Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia
2Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore 641004, TN, India
3Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore 641002, TN, India
4Department of Pharmaceutical Analysis, PSG College of Pharmacy, Coimbatore 641004, TN, India
5Department of Pharmaceutics, Karpagam College of Pharmacy, Coimbatore 641032, TN, India

EDITOR / REVIEWER

Christian Celia