Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation (London, England) · 10 authors, 1 centre

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Limitations include the need for further in vivo blocking assays to confirm the pathway's role and the lack of investigation into the PERK signaling pathway.

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Limitations include the need for further in vivo blocking assays to confirm the pathway's role and the lack of investigation into the PERK signaling pathway.

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other

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preclinical research

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ORIGINAL PAPER

PMC10621191

Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway

Journal of Inflammation (London, England)

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ABSTRACT

Abstract Background Soluble Epoxide Hydrolase (sEH) metabolizes anti-inflammatory epoxyeicosatrienoic acids and critically affects airway inflammation in chronic obstructive pulmonary disease (COPD). Considering the excessive endoplasmic reticulum stress is associated with the earlier onset of COPD. The role of sEH and endoplasmic reticulum stress in the pathogenesis of COPD remains unknown. Method 16 weeks of cigarette-exposed mice were used to detect the relationship between sEH and endoplasmic reticulum stress in COPD. Human epithelial cells were used in vitro to determine the regulation mechanism of sEH in endoplasmic reticulum stress induced by cigarette smoke. Results sEH deficiency helps reduce emphysema formation after smoke exposure by alleviating endoplasmic reticulum stress response. sEH deficiency effectively reverses the upregulation of phosphorylation IRE1α and JNK and the nuclear expression of AP-1, alleviating the secretion of inflammatory factors induced by cigarette smoke extract. Furthermore, the treatment with endoplasmic reticulum stress and IRE1α inhibitor downregulated cigarette smoke extract-induced sEH expression and the secretion of inflammatory factors. Conclusion sEH probably alleviates airway inflammatory response and endoplasmic reticulum stress via the IRE1α/JNK/AP-1 pathway, which might attenuate lung injury caused by long-term smoking and provide a new pharmacological target for preventing and treating COPD. Keywords: Soluble epoxide hydrolase, Endoplasmic reticulum stress, Inflammation, Cigarette smoke, COPD

CITATION EXPORT

Yue Yu, Ailin Yang, Xin He et al.. Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway. Journal of Inflammation (London, England). (2023). https://doi.org/10.1186/s12950-023-00361-y

AUTHORS

10 · 1 CENTRES

Yue Yu, Ailin Yang, Xin He, Bo Wu, Yanjun Wu, Yunxiao Li, Shan Nie, Bo Xu, Haoyan Wang, Ganggang Yu

1Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, No, 95 Yong An Road, Xichen District, Beijing, 100050 China

Yue Yu, Ailin Yang, Xin He et al.. Soluble epoxide hydrolase deficiency attenuates airway inflammation in COPD via IRE1α/JNK/AP-1 signaling pathway. Journal of Inflammation (London, England). (2023). https://doi.org/10.1186/s12950-023-00361-y