SEARCHSYSTEMATIC_REVIEWnutrition, dietetics

systematic_review·nutrition, dietetics, clinical nutrition, systematic review·PMC10560784

Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans

Heliyon · 4 authors, 2 centres

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TL;DR

This PRISMA-registered systematic review of 33 studies examined plant-derived compounds that inhibit sweet taste perception in healthy humans and their downstream effects on eating behavior.

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This systematic review followed PRISMA and SIGN guidelines and searched five databases, identifying 33 peer-reviewed studies on plant-derived bioactive compounds that suppress sweet taste perception in healthy individuals. The relationship between sweet taste suppression and food intake appeared to be continuous and dose-dependent rather than following a binary threshold.

STUDY TYPE

systematic_review

SPECIALTY

nutrition

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ORIGINAL PAPER

PMC10560784

Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans

Heliyon

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ABSTRACT

The taste of food plays a crucial role in determining what and how much we eat. Thus, interventions that temporarily block sweet taste receptors offer a promising approach to addressing unhealthy behaviours associated with sugary foods. However, the relationship between reduced sweet taste response and food consumption remains unclear, with contradictory findings. Certain studies suggest that a diminished perception of sweetness leads to a sense of fullness and results in reduced food intake, while others suggest the opposite effect. To shed some light, our systematic review looked into the relationship between diminished sweet taste response and food consumption by examining the effects of bioactive compounds that experimentally inhibit sweetness in healthy individuals. This review was registered in the International Prospective Register of Systematic Reviews and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Scottish Intercollegiate Guidelines Network, and covered original papers included in Web of Science, PubMed, Scopus, Food Science Source and Food Science and technology abstracts. We identified 33 peer-reviewed English-language studies that fit the topic and met the inclusion criteria. The current literature predominantly focuses on the immediate impact of oral gymnemic acids, failing to provide preliminary evidence in support of the specific threshold hypothesis, above which food consumption decreases and below which the opposite effect occurs. Additionally, there was inconsistency in the findings regarding the short-term desire to eat following sweetness inhibition. Considering the downstream effects on energy intake and their clinical applications, further research is needed to clarify both the acute within-session effects (i.e., not wanting any more now) and the longer-term effects (i.e., deciding not to start eating) linked to oral sweet-taste-suppressing compounds.

CITATION EXPORT

Raquel Rayo-Morales, Antonio Segura-Carretero, Isabel Borras-Linares et al.. Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans. Heliyon. (2023). https://doi.org/10.1016/j.heliyon.2023.e19733

AUTHORS

4 · 2 CENTRES

Raquel Rayo-Morales, Antonio Segura-Carretero, Isabel Borras-Linares, David Garcia-Burgos

aDepartment of Analytical Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain
bDepartment of Psychobiology, Institute of Neurosciences, Centre for Biomedical Research, University of Granada, 18010, Granada, Spain

Raquel Rayo-Morales, Antonio Segura-Carretero, Isabel Borras-Linares et al.. Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans. Heliyon. (2023). https://doi.org/10.1016/j.heliyon.2023.e19733