SEARCHNARRATIVE_REVIEWresearch methods, biomedical research

narrative_review·research methods, biomedical research, preclinical research·PMC10608848

Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems

Metabolites · 1 author, 3 centres

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This narrative review discusses biocatalytic systems as key tools for synthesizing diverse metabolites and metabolite-like compounds. It highlights that biocatalysis offers resource-efficient, straightforward routes inspired by natural metabolic pathways.

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This narrative review describes methodologies for the synthesis of metabolites and metabolite-like compounds, focusing on biocatalytic systems. The review outlines how knowledge of natural metabolic pathways can inspire simplified, resource-efficient synthetic routes. Key advantages of biocatalysis include high selectivity, reduced need for protecting groups, and the ability to produce complex molecules like the antiviral islatravir in fewer steps. The text notes that biocatalytic production is preferred when natural extraction yields are low or chemical routes are lengthy. Implications center on enabling the production of standards, drug metabolites, and novel compounds for biological discovery.

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narrative_review

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research methods

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ORIGINAL PAPER

PMC10608848

Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems

Metabolites

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ABSTRACT

Methodologies for the synthesis and purification of metabolites, which have been developed following their discovery, analysis, and structural identification, have been involved in numerous life science milestones. The renewed focus on the small molecule domain of biological cells has also created an increasing awareness of the rising gap between the metabolites identified and the metabolites which have been prepared as pure compounds. The design and engineering of resource-efficient and straightforward synthetic methodologies for the production of the diverse and numerous metabolites and metabolite-like compounds have attracted much interest. The variety of metabolic pathways in biological cells provides a wonderful blueprint for designing simplified and resource-efficient synthetic routes to desired metabolites. Therefore, biocatalytic systems have become key enabling tools for the synthesis of an increasing number of metabolites, which can then be utilized as standards, enzyme substrates, inhibitors, or other products, or for the discovery of novel biological functions.

CITATION EXPORT

Roland Wohlgemuth. Synthesis of Metabolites and Metabolite-like Compounds Using Biocatalytic Systems. Metabolites. (2023). https://doi.org/10.3390/metabo13101097

AUTHORS

1 · 3 CENTRES

Roland Wohlgemuth

1MITR, Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Zeromskiego Street 116, 90-924 Lodz, Poland; [email protected]
2Swiss Coordination Committee Biotechnology (SKB), 8021 Zurich, Switzerland
3European Society of Applied Biocatalysis (ESAB), 1000 Brussels, Belgium

EDITOR / REVIEWER

Christian Bock