SEARCHNARRATIVE_REVIEWoncology, preclinical research

narrative_review·oncology, preclinical research, biomedical research, nutrition, immunology·PMC10161514

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Biomarker Research · 7 authors, 4 centres

AI SUMMARY

FIDELITY 100%

This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.

AGENT 01 · STRUCTURED SUMMARY

TRACE TO SOURCE

“

TL;DR

This narrative review examines how the serine-glycine-one-carbon (SGOC) metabolic pathway supports cancer cell survival and proliferation, making it a potential therapeutic target. The central result is that inhibiting specific SGOC enzymes or restricting dietary serine/glycine can enhance anti-tumor effects in preclinical models.

Full summary

740 CHARS

This is a narrative review synthesizing preclinical research on the SGOC metabolic pathway's role in cancer. The authors describe how SGOC metabolism provides essential building blocks for nucleotides, lipids, and methylation reactions, which are co-opted by tumors for proliferation. The review summarizes evidence from cell line and mouse studies showing that inhibiting key enzymes like PHGDH or using dietary serine/glycine restriction can slow tumor growth. It also discusses links between SGOC metabolism and cancer immunotherapy, noting that the drug pemetrexed can enhance T-cell activation in mouse models. The review suggests targeting SGOC metabolism as a promising strategy to overcome drug resistance and improve immunotherapy.

STUDY TYPE

narrative_review

SPECIALTY

oncology

SUMMARISED BY

AI pipeline

FIDELITY CHECK

100% · A

ORIGINAL PAPER

PMC10161514

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Biomarker Research

READ THE FULL PAPER

ABSTRACT

The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis. The SGOC pathway is a crucial metabolic network in tumorigenesis, wherein the outputs are required for cell survival and proliferation and are particularly likely to be co-opted by aggressive cancers. SGOC metabolism provides an integration point in cell metabolism and is of crucial clinical significance. The mechanism of how this network is regulated is the key to understanding tumor heterogeneity and overcoming the potential mechanism of tumor recurrence. Herein, we review the role of SGOC metabolism in cancer by focusing on key enzymes with tumor-promoting functions and important products with physiological significance in tumorigenesis. In addition, we introduce the ways in which cancer cells acquire and use one-carbon unit, and discuss the recently clarified role of SGOC metabolic enzymes in tumorigenesis and development, as well as their relationship with cancer immunotherapy and ferroptosis. The targeting of SGOC metabolism may be a potential therapeutic strategy to improve clinical outcomes in cancers.

CITATION EXPORT

Wei Sun, Ruochen Liu, Xinyue Gao et al.. Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers. Biomarker Research. (2023). https://doi.org/10.1186/s40364-023-00487-4

AUTHORS

7 · 4 CENTRES

Wei Sun, Ruochen Liu, Xinyue Gao, Zini Lin, Hongao Tang, Hongjuan Cui, Erhu Zhao

1grid.263906.80000 0001 0362 4044State Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, No.2 Tiansheng Road, Beibei District, 400716 Chongqing, China
2Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing, 400716 China
3grid.263906.80000 0001 0362 4044Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing, 400715 China
4Jinfeng Laboratory, Chongqing, 401329 China