SEARCHNARRATIVE_REVIEWoncology, neurology

narrative_review·oncology, neurology, preclinical research, biomedical research·PMC10573820

Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment

International Journal of Molecular Sciences · 2 authors, 2 centres

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TL;DR

It suggests that targeting this crosstalk is a promising therapeutic strategy, though validated in vivo models are needed.

Full summary

330 CHARS

The review notes significant limitations, including a lack of robust in vivo models to study the interaction and cancer-associated pain. Implications suggest that combination therapies targeting multiple aspects of the tumor microenvironment, including the neuronal axis, represent a future direction for improving PDAC treatment.

STUDY TYPE

narrative_review

SPECIALTY

oncology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10573820

Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment

International Journal of Molecular Sciences

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ABSTRACT

Abstract Pancreatic ductal adenocarcinoma (PDAC) represents one of the most aggressive solid tumors with a dismal prognosis and an increasing incidence. At the time of diagnosis, more than 85% of patients are in an unresectable stage. For these patients, chemotherapy can prolong survival by only a few months. Unfortunately, in recent decades, no groundbreaking therapies have emerged for PDAC, thus raising the question of how to identify novel therapeutic druggable targets to improve prognosis. Recently, the tumor microenvironment and especially its neural component has gained increasing interest in the pancreatic cancer field. A histological hallmark of PDAC is perineural invasion (PNI), whereby cancer cells invade surrounding nerves, providing an alternative route for metastatic spread. The extent of PNI has been positively correlated with early tumor recurrence and reduced overall survival. Multiple studies have shown that mechanisms involved in PNI are also involved in tumor spread and pain generation. Targeting these pathways has shown promising results in alleviating pain and reducing PNI in preclinical models. In this review, we will describe the mechanisms and future treatment strategies to target this mutually trophic interaction between cancer cells to open novel avenues for the treatment of patients diagnosed with PDAC. Keywords: pancreatic ductal adenocarcinoma, microenvironment, neuron, crosstalk

CITATION EXPORT

Ylenia Capodanno, Michael Hirth. Targeting the Cancer–Neuronal Crosstalk in the Pancreatic Cancer Microenvironment. International Journal of Molecular Sciences. (2023). https://doi.org/10.3390/ijms241914989

AUTHORS

2 · 2 CENTRES

Ylenia Capodanno, Michael Hirth

1Institute of Pharmacology, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 366, 69117 Heidelberg, Germany
2Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1–3, 68167 Mannheim, Germany