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TL;DR
This pilot study of 53 hospitalized cancer patients at malnutrition risk used Antera 3D imaging to quantify facial depression indices, finding temporal and periorbital depressions significantly associated with muscle and fat loss phenotypes.
Frontiers in Nutrition · 7 authors, 4 centres
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This pilot study of 53 hospitalized cancer patients at malnutrition risk used Antera 3D imaging to quantify facial depression indices, finding temporal and periorbital depressions significantly associated with muscle and fat loss phenotypes.
This pilot observational study recruited 53 hospitalized patients receiving maintenance chemotherapy for advanced digestive system malignancies who had NRS 2002 scores greater than 3, indicating malnutrition risk. Trained physicians performed subjective global assessments alongside physical examination and body composition analysis. The Antera 3D system quantified temporal and periorbital depression volume, affected area, and maximum depth. Temporal depression volume was significantly negatively correlated with upper arm circumference (r = −0.293, p = 0.033) and calf circumference (r = −0.285, p = 0.038). The authors noted limitations including small sample size, use of BIA rather than DXA/CT/MRI for body composition, and limited facial feature data extraction yielding modest correlations of 0.2 to 0.4. Findings suggest 3D facial imaging may serve as an auxiliary tool for malnutrition screening, though further validation in larger populations is needed.