SEARCHSYSTEMATIC_REVIEWnephrology, infectious disease

systematic_review·nephrology, infectious disease, systematic review, internal medicine, epidemiology·PMC10590624

Tenofovir-Induced Renal Dysfunction Among HIV-Infected Patients: A Systematic Review

Cureus · 7 authors, 7 centres

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TL;DR

This systematic review synthesizes evidence on tenofovir-induced renal dysfunction in HIV-infected patients.

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This systematic review synthesizes evidence on tenofovir-induced renal dysfunction in HIV-infected patients. The central conclusion is that TDF-based antiretroviral therapy is associated with an increased risk of renal impairment.

STUDY TYPE

systematic_review

SPECIALTY

nephrology

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AI pipeline

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100% · A

ORIGINAL PAPER

PMC10590624

Tenofovir-Induced Renal Dysfunction Among HIV-Infected Patients: A Systematic Review

Cureus

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ABSTRACT

Abstract Tenofovir disoproxil fumarate (TDF) is an antiretroviral drug widely used as part of antiretroviral therapy (ART) to treat human immunodeficiency virus (HIV-1) infection. Negative effects of tenofovir include impaired kidney function, especially with long-term use. In studies conducted among HIV-positive individuals, we found evidence of extensive kidney damage associated with TDF use. Despite the therapeutic importance of this consequence, its continued use in ART regimens was not contraindicated. The therapeutic and long-term effects of TDF are a major concern. However, in countries or settings where resources are limited and renal function monitoring cannot be ensured, screening methods to detect ART-related renal failure are still supported by data. Therefore, it is safe to re-evaluate the use of TDF-based ART. However, adherence to guidelines may be hampered by insufficient laboratory testing in low- and middle-income countries. More research is also needed among people under 18 years of age and pregnant and breastfeeding mothers. Keywords: tenofovir alafenamide (taf), glomerular and tubular injury, kidney failure, hiv aids, tenofovir disoproxil fumarate (tdf)

CITATION EXPORT

Yogamba M Shivakumar, Eshwar Burra, Kamran Shahid et al.. Tenofovir-Induced Renal Dysfunction Among HIV-Infected Patients: A Systematic Review. Cureus. (2023). https://doi.org/10.7759/cureus.45787

AUTHORS

7 · 7 CENTRES

Yogamba M Shivakumar, Eshwar Burra, Kamran Shahid, Yonas Tamene, Shefali P Mody, Kaiser O Sadiq, Sai Sri Penumetcha

1 Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA
2 Internal Medicine, Government Medical College, Nizamabad, IND
3 Internal Medicine/Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA
4 Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA
5 Surgery, Plexus Neuro and Stem Cell Research Centre, Bangalore, IND
6 General Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA
7 General Medicine, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, IND