PLOS ONE · 13 authors, 11 centres
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
Using data from 23,657 NHANES participants without HIV, this cohort study found that all major CDC-defined HIV acquisition risk groups—people who ever injected drugs, men who have sex with men, and heterosexually active people at increased risk—had significantly higher all-cause mortality compared with heterosexually active people at average risk for HIV.
Cox proportional hazards models estimated adjusted hazard ratios comparing ever-PWID, MSM, and heterosexually active people at increased risk (HIH, using low income as proxy) with heterosexually active people at average risk (HAH). Female ever-PWID had the highest adjusted mortality risk (HR 3.50), followed by female HIH (HR 2.35), male HIH (HR 1.68), male ever-PWID (HR 1.67), and MSM (HR 1.51). NHANES likely underrepresents actively injecting or institutionalized individuals, suggesting these estimates may be conservative. Findings suggest that social determinants driving HIV risk also contribute to excess mortality independent of HIV status.
