Brain and Behavior · 6 authors, 1 centre
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A nonlinear relationship was detected with an inflection point at 1.55 mmol/L; below this threshold each unit increase in HDL-C was associated with a 64% lower stroke risk (OR=0.36, 95% CI: 0.21–0.62), while above it the association was not significant (OR=1.29, 95% CI: 0.79–2.09).
A nonlinear relationship was detected with an inflection point at 1.55 mmol/L; below this threshold each unit increase in HDL-C was associated with a 64% lower stroke risk (OR=0.36, 95% CI: 0.21–0.62), while above it the association was not significant (OR=1.29, 95% CI: 0.79–2.09). Subgroup analyses showed the inverse association persisted in men and White participants but not in women or other racial/ethnic groups. The cross-sectional design precludes causal inference, stroke subtypes were not differentiated, and subgroup analyses were exploratory.
