SEARCHCROSS-SECTIONALophthalmology, glaucoma

cross-sectional·ophthalmology, glaucoma, cardiology, epidemiology, observational study·PMC10444694

The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts

Ophthalmology · 13 authors, 10 centres

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TL;DR

This cross-sectional study analyzed two large UK cohorts to find that higher levels of total cholesterol, HDL cholesterol, and LDL cholesterol were independently associated with higher corneal-compensated intraocular pressure (IOP).

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Using multivariate linear regression adjusted for numerous covariates, the study found that higher levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were independently associated with higher IOPcc in both cohorts. An inverse association for triglycerides was seen only in the UK Biobank cohort.

STUDY TYPE

cross-sectional

SPECIALTY

ophthalmology

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ORIGINAL PAPER

PMC10444694

The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts

Ophthalmology

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ABSTRACT

Abstract Purpose Serum lipids are modifiable, routinely collected blood test features associated with cardiovascular health. We examined the association of commonly collected serum lipid measures (total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides) with intraocular pressure (IOP). Design Cross-sectional study in the UK Biobank and European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohorts. Participants We included 94 323 participants from the UK Biobank (mean age, 57 years) and 6230 participants from the EPIC-Norfolk (mean age, 68 years) cohorts with data on TC, HDL-C, LDL-C, and triglycerides collected between 2006 and 2009. Methods Multivariate linear regression adjusting for demographic, lifestyle, anthropometric, medical, and ophthalmic covariables was used to examine the associations of serum lipids with corneal-compensated IOP (IOPcc). Main Outcome Measures Corneal-compensated IOP. Results Higher levels of TC, HDL-C, and LDL-C were associated independently with higher IOPcc in both cohorts after adjustment for key demographic, medical, and lifestyle factors. For each 1-standard deviation increase in TC, HDL-C, and LDL-C, IOPcc was higher by 0.09 mmHg (95% confidence interval [CI], 0.06–0.11 mmHg; P < 0.001), 0.11 mmHg (95% CI, 0.08–0.13 mmHg; P < 0.001), and 0.07 mmHg (95% CI, 0.05–0.09 mmHg; P < 0.001), respectively, in the UK Biobank cohort. In the EPIC-Norfolk cohort, each 1-standard deviation increase in TC, HDL-C, and LDL-C was associated with a higher IOPcc by 0.19 mmHg (95% CI, 0.07–0.31 mmHg; P = 0.001), 0.14 mmHg (95% CI, 0.03–0.25 mmHg; P = 0.016), and 0.17 mmHg (95% CI, 0.06–0.29 mmHg; P = 0.003). An inverse association between triglyceride levels and IOP in the UK Biobank (–0.05 mmHg; 95% CI, –0.08 to –0.03; P < 0.001) was not replicated in the EPIC-Norfolk cohort ( P = 0.30). Conclusions Our findings suggest that serum TC, HDL-C, and LDL-C are associated positively with IOP in 2 United Kingdom cohorts and that triglyceride levels may be associated negatively. Future research is required to assess whether these associations are causal in nature. Keywords: Cholesterol, Glaucoma, Intraocular pressure, Lipids

CITATION EXPORT

Kian M Madjedi, Kelsey V Stuart, Sharon YL Chua et al.. The Association between Serum Lipids and Intraocular Pressure in 2 Large United Kingdom Cohorts. Ophthalmology. (2022). https://doi.org/10.1016/j.ophtha.2022.04.023

AUTHORS

13 · 10 CENTRES

Kian M Madjedi, Kelsey V Stuart, Sharon YL Chua, Robert N Luben, Alasdair Warwick, Louis R Pasquale, Jae H Kang, Janey L Wiggs, Marleen AH Lentjes, Hugues Aschard, Naveed Sattar, Paul J Foster, Anthony P Khawaja

1NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust & UCL Institute of Ophthalmology, London, United Kingdom
2Department of Ophthalmology, University of Calgary, Calgary, Canada
3MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
4UCL Institute of Cardiovascular Science, University College London, London, United Kingdom
5Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York
6Brigham and Women’s Hospital / Harvard Medical School, Boston, Massachusetts
7Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts
8Clinical Epidemiology and Biostatistics/Nutrient Gut-Brain Interaction, Örebro University, Örebro, Sweden
9Institute Pasteur, Paris, France
10BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom