Open Medicine · 11 authors, 6 centres
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This cross-sectional study of 1,073 patients found no overall association between sleep characteristics and NAFLD, but after adjusting for confounders, men with long sleep duration had a significantly lower risk of NAFLD compared to those with short sleep duration.
This cross-sectional study assessed associations between sleep duration, quality, and NAFLD in 1,073 patients using the Pittsburgh Sleep Quality Index and Munich Chronotype Questionnaire for sleep assessment and ultrasonography for NAFLD diagnosis. Multivariate logistic regression was used for analysis. The study found no significant differences in sleep parameters between NAFLD and non-NAFLD groups overall. However, after adjusting for age, exercise, fasting plasma glucose, and BMI, men in the long sleep duration group showed a significantly decreased risk of NAFLD (OR=0.01, 95% CI: 0.001–0.27, P=0.032) compared to a reference group. No significant associations were found in women. The authors note limitations including the use of a subjective sleep questionnaire, the cross-sectional design precluding causal inference, and uncontrolled factors like nutrition and genetics.
